I didn’t really expect the Godfather to figure prominently in any of my blog posts, but I thought that paraphrasing Michael Corleone here might be a good way to start a discussion about addiction as a disease vs. addiction as a choice. It is my experience that family members (and addicts themselves) still struggle greatly with the feeling that excessive drug and alcohol use are essentially moral problems. So I think it’s always important, in treatment, to look at the mounting evidence that addiction to substances, as well as certain compulsive activities, actually change the brain in ways that undermine the ability to make healthy choices. Learning about the neurological impact of addiction can help everyone affected by it to find compassion for their struggle with a devastating illness.
There is an ever-increasing amount of data, including results from neuroimaging studies, that support the definition of addiction held by the American Society of Addiction Medicine, which is that,”Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry”. Today we understand for example, how substance abuse and even activities like gambling, affect the action of dopamine in the brain. Dopamine is the substance released by neurons in the reward centers of the brain whenever we do something pleasurable. The brain has evolved to reward us for doing things useful to the survival of the species–such as eating and procreating, and a flood of dopamine is the reward we get for participating in these activities. However, drugs of abuse, gambling, binge-eating and even excessive internet use can cause the reward centers of the brain to release far more dopamine than we’re used to getting, and if this happens on a regular basis, the brain remodels itself to defend against the flood of dopamine it’s receiving. It begins to produce less of the stuff on its own and it becomes less sensitive to it as well. As addicts develop this “tolerance” to their drug or activity of choice, they need more and more of it to achieve the pleasure they’re used to getting from their habit, and the brain’s reluctance to produce dopamine on its own means that they also feel less pleasure from doing the things that used to make them happy. Consequently, drug rewards eventually become more important to addicts than anything else. I believe addicts when they tell me that their need to get high actually makes them stop thinking about other things, including food and including people, that are otherwise important to them. I believe them because what they’re saying is completely consistent with changes that technology now allows us to see in the reward centers of addicts’ brains.
Other parts of addicts’ brains change too. In addition to this malfunction of the reward circuitry, there is a weakening of the executive control mechanisms in the pre-frontal cortex. This is the part of the brain that helps people to regulate emotions and impulsive behavior. So heavy drinking (including intermittent binge drinking) undermines the very functions that are needed to make healthy decisions about future drinking. Moreover, the brain isn’t so quick to heal once someone abstains from alcohol and other drug use. A recent study of current and former cocaine users for example, found that even after 4 years of abstinence, there were abnormalities in some brain regions involved with reward processing.